Reference tool — not medical advice. Thresholds, targets, and first-line agents differ by guideline body and change over time — switch the lens to compare. Clinician judgement, dosing/monitoring, contraindications, and live coverage always required. Runs entirely in your browser — no data is collected.

Smoking cessation selector

Choose the guideline lens (CTFPHC / USPSTF / NICE), the dependence, comorbidities and preferences — get the pharmacotherapy (varenicline, combination NRT, bupropion, cytisine) always paired with counselling, with pregnancy and e-cigarette handling that differ by society.

Guideline lens

Nicotine dependencechoose one

Cigarettes/day, time to first cigarette

Comorbidities

Prior attempts

Preferences

Always

Combine behavioural support/counselling WITH pharmacotherapy — never medication alone

Framing

CTFPHC frames the agents as a MENU of equally-recommended options (varenicline has the largest effect)

E-cigarettes

CTFPHC: conditionally AGAINST — reserve for those who fail other options / strongly prefer it

Notes

• CTFPHC 2025 deliberately avoids a strict hierarchy — varenicline, combination NRT, bupropion, single NRT and cytisine are framed as a menu of equally-recommended options, chosen by shared decision (varenicline has the largest point estimate). E-cigarettes are conditionally against.
• Prescribe GENERIC varenicline — brand Champix was recalled and cancelled in Canada. ODB and programs (CAMH STOP, Smokers' Helpline) provide free/covered NRT.

Suggested drug classesPer CTFPHC (Canada) 2025.

Select dependence level to begin.

Switch the lens to see the e-cigarette split: CTFPHC (against) vs USPSTF (insufficient) vs NICE (recommends).

Guidelines

2025CTFPHC (Canada) — Canadian Task Force on Preventive Health Care — tobacco smoking cessation in adults (CMAJ 2025). Menu of equally-recommended agents; conditional against e-cigarettes. link
2021USPSTF — US Preventive Services Task Force — Interventions for Tobacco Smoking Cessation (2021). E-cigarettes: evidence insufficient. link
2024NICE — NICE NG209 — Tobacco: treating dependence (2021, updated 2023; 2024 surveillance adds cytisine). Recommends e-cigarettes. link

References

[1]Canadian Task Force on Preventive Health Care — Recommendations on interventions for tobacco smoking cessation in adults. CMAJ 2025;197:E846 (menu of equally-recommended agents; conditional against e-cigarettes; supersedes CAN-ADAPTT 2011). link
[2]USPSTF — Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Persons (2021). JAMA 2021;325:265. E-cigarettes: evidence insufficient. link
[3]NICE NG209 — Tobacco: preventing uptake, promoting quitting and treating dependence (2021, updated 2023; 2024 surveillance adds cytisine; recommends e-cigarettes). EAGLES trial (Lancet 2016) — CV/neuropsychiatric safety of varenicline/bupropion. link